Premature ovarian failure (POF), also known as primary ovarian insufficiency (POI), is a condition characterized by loss of normal function of the ovaries before age 40. The ovaries stop producing normal levels of the hormone estrogen, which can cause symptoms like irregular periods, infertility, and menopause-like effects.
Some key facts about POF/POI:
- It impacts about 1% of women under age 40.
- The cause is often unknown, but can involve genetics, autoimmune disorders, infections, or treatments like chemotherapy.
- Diagnosis is typically made by blood tests showing high follicle stimulating hormone (FSH) levels.
- Treatment focuses on managing symptoms and often includes hormone replacement therapy (HRT).
Symptoms of POF/POI may include:
- Irregular or missed menstrual periods
- Hot flashes
- Vaginal dryness
- Difficulty conceiving a pregnancy
Diagnosing POF/POI begins with a medical history and
pelvic exam.
Blood tests to measure hormone levels like FSH and
estradiol can confirm the diagnosis. Sometimes genetic testing is done to look for chromosomal abnormalities associated with POF/POI.
Treatment is tailored to the patient’s needs and goals. HRT with estrogen and progesterone can help relieve menopause-like effects. Infertility treatment options may include
in vitro fertilization (IVF) with donor eggs. Support groups and counselling resources can also help patients.
If you’re dealing with POF/POI, the caring physicians at Vitality Renewal Clinic offer personalized care including hormone testing and HRT options to help manage symptoms. We work closely with top fertility specialists if pregnancy is a goal. Contact us today for a consultation to discuss your treatment options.
The course of POF/POI varies. Some patients may have intermittent ovarian function where periods occasionally return temporarily. For others, the loss of ovarian function is permanent. With treatment, most women can effectively manage symptoms and improve quality of life.